blood in the urine. Here are some basic guidelines as reported by WebMD: While most studies do not indicate major side effects, pine bark extract may cause irritability and fatigue, and could interact with other drugs. Moreover, Pycnogenol treatment led to an increase in sperm count and testosterone levels with lowering of blood pressure and cholesterol levels. Disclaimer: Results are not guaranteed*** and may vary from person to person***. Another study found this supplement can even halt progression of vision . We avoid using tertiary references. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. This article reviews tongkat ali, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. The results of a 2013 animal study suggest that pine bark extract may help to reduce damage to nerve cells following a traumatic brain injury. Blood clots form as a result of platelet aggregation, which is the platelets in the blood clumping together. Add to Cart. But a month after pycnogenol was stopped, the symptoms came back, suggesting that it may need to be used regularly to achieve the benefits [41]. After taking a break for one to two weeks, they can start taking it again for several weeks. Low-dose Pycnogenol (30 mg/day) may reduce pain in pregnant women, particularly hip, joint, lower back, groin, and calf cramps in the third trimester [71]. In the study, women taking Pycnogenol were more satisfied and compliant to the regimen [24]. Grape seed extract may have heart-health benefits. Vertigo. In contrast, bleeding still occurred in the control group [61]. Traditionally, people might drink a brew made from pine bark -- rich in pycnogenol -- as a treatment. Pycnogenol treatment lowered the ACE-inhibitor dose required to control blood pressure, and lowered fasting glucose levels as well. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. Researchers suggest that Pycnogenol may reduce cough, night-awakenings, improve airway flow, and the need for additional asthma medication [16]. According to a study in 59 cancer patients, Pycnogenol (150 mg/day) may reduce side effects associated with radiation or chemotherapy, including mouth soreness and ulcers, mouth and eye dryness, nausea, vomiting, diarrhea and weight loss [78]. Pycnogenol is a patented extract of the French maritime pine bark (Pinus pinaster). Pycnogenol seems to help with asthma and allergies. A randomized, double-blind, placebo-controlled study of 60 patients aged six to 18 years old, was conducted over three months during which patients were randomly assigned to receive either Pycnogenol or placebo. All rights reserved. ", Mayo Clinic: High blood pressure (hypertension)., Panminerva Medica: "Pycnogenol improvements in asthma management. Top 9 Natural Allergy Relief Home Remedies - Dr. Axe 1 week ago from draxe.com Eat an Anti-Inflammatory, Alkaline Diet. Another highlight of grapes nutrition is the presence of polyphenols, which have been shown to decrease chronic inflammation. Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common . Learn about this tree-based pill and how it might be able to help you. Fundukian, L.J. In a good-quality study, 24 adults aged 24 to 53 years old with attention deficit hyperactivity disorder (ADHD) were given Pycnogenol, placebo, or the standard drug for three weeks. Upset stomach. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Studies have found that when taken along with an inhaler, Pycnogenol can reduce leukotrienes, helping to relieve lung inflammation and limit frequency of inhaler use., Many people develop osteoarthritis as they age. 1. Most have similar amounts of active substances and are often sold under the brand name Pycnogenol [6]. In 7 volunteers, Pycnogenol (300 mg) for 5 days may reduce the activity of a crucial inflammatory gene (NF-B) [53]. Pycnogenol seems well-tolerated for use in adults for up to 6 months. Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT. Pycnogenol pine bark extracts contain a unique blend of flavonoids whose antioxidant action is over is 50 times more powerful than vitamin E, 20 times more powerful than vitamin C and 16 times more active than grapeseed extracts. Systolic blood pressure measures how much blood is pumping from your heart to your arteries. But did you know that pine bark extract, like pine oil, is one of natures super antioxidants? Pycnogenol is known under different names in some countries, such as Oligopin, and Flavangenol in Japan [4, 5]. It also seems to help with cell regeneration and replication. Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. The flesh of the grape contains approximately 1/20th-1/100th of the total antioxidant capacity of the seed or the skin. Grape seed extract may be more beneficial for those who are obese. Helps Treat Erectile Dysfunction. In this article, well summarize all the potential benefits and the scientific research surrounding pine bark extract and Pycnogenol. Rating: 100%. As noted, aspirin can cause severe gastrointestinal issues. (2006). Lower the risk of Alzheimer's disease. Perimenopausal women who took pine bark extract for eight weeks noticed decreased cholesterol and triglyceride levels. ", American Heart Association: Understanding Blood Pressure Readings., Iranian Journal of Public Health: "Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis. Its used as a natural supplement for several conditions, including dry skin and ADHD. Interesting activities, new dishes in restaurants, specialty ingredients, explanations of some netizens questions, etc.Hu Xuan is even helping Fatty s company s tourism manager, managing with Vice President Du Meixin, such as arranging guests reasonably.By the way.Dad, I want to tell you something.I plan to invest in the hotels and entertainment centers in the . A systematic review of 14 studies found that Pycnogenol gum or mouthwashes may reduce dental plaque, but the quality of evidence is low [58, 59]. A deficiency can cause issues like anemia, stunted growth, heart problems and neural tube defects. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. Interactions. DOI: Gulati OP. In another good study, 48 patients with diabetes and high blood pressure on ACE inhibitors were randomized to receive either Pycnogenol 125 mg daily or placebo for 12 weeks. All of our content is written by scientists and people with a strong science background. A study of 66 healthy adults found that Pycnogenol may reduce the number of leg cramps experienced [11]. A plus sign next to the number [1+, 2+, etc] means that the information is found within the full scientific study rather than the abstract. There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. Diabetes-associated small blood vessel changes is the leading cause of diabetic ulcers. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. The results showed that the combination of local and systemic applications of Pycnogenol were the best in terms of ulcer healing even though local application of Pycnogenol also speeded up ulcer healing. chronic anal fissure may take more than 6 weeks to heal. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. (8). Pycnogenol (pic-noj-en-all) is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits. Start with a low dose so you can be sure it doesnt cause any side effects. (10), A 15-year Dutch study was published stating that 27,939 healthy female health professionals were given aspirin or a placebo for a period of time. The same ingredient can be found in grapeseed oil, the skin of peanuts and witch hazel bark. 5 6 However, evidence is conflictingother studies have shown no effect on the same measures. It does this by improving the time it takes the body to reach a fatigued state through increased serum NAD+ levels. which enables users to obtain detailed information and reports based on their genome. For most people, pine bark extract doesnt cause any side effects. Pycnogenol is the US trademarked name for an antioxidant made from Mediterranean tree bark. (14, 15). Ask your doctor for advice. One study involved a four-week treatment period followed by one week of no treatment or observation period. Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. It also may help regenerate and maintain vitamin C and E levels while also potentially increasing nitric oxide levels, which may relax and protect blood vessels [1]. However, with the addition of twice-daily Pycnogenol, normal erection increased to 80%, which further increased to 92.5% during the third month on thrice-daily Pycnogenol. The first studied group included 66 healthy subjects in whom the number of muscle cramps was recorded two weeks before entering the study and during the fourth and fifth week. Chestnut seed extract did not do as well. Cigarette smoking increases platelet aggregation. WebMD does not provide medical advice, diagnosis or treatment. Our team aims to be not only thorough with its research, but also objective and unbiased. However, in all the above studies insulin levels did not change. During the first month on L-arginine, only five percent of patients experienced normal erection. Another group of men who took just l-arginine didnt improve [66]. Some health benefits of Pycnogenol include:. Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins . From diabetes and sexual function to sports performance and beautiful skin, pine bark extract may be worth exploring to provide results youre looking to achieve. Pycnogenol in metabolic syndrome and related disorders [Abstract]. WebMD does not provide medical advice, diagnosis or treatment. Four hundred years later, a French researcher named Jacques Masquelier did some studies to understand why this natural remedy was so effective. If you knew you could resolve your erectile dysfunction and, therefore, naturally remedy impotence issues, wouldnt you? It is chronic venous insufficiency, a common disease among people who are obese or elderly and those who lead a sedentary lifestyle. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. Learn more about how to get even skin tone. Some risks associated with Pycnogenol include:, Pycnogenol and other maritime tree barks have not been studied as extensively as traditional medicine. Note that the numbers in parentheses (1, 2, etc.) According to some researchers, Pycnogenol may lower blood pressure by relaxing blood vessels, reducing free radicals, and lowering inflammation. Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. Mental function. A study of 147 people found that pycnogenol (100 mg/day) may improve running, push-ups, and sit-ups endurance in recreational athletes over an 8-week training program. A trial of 86 people with eye damage from diabetes found that antioxidant therapy (including pycnogenol, vitamin E, and Coenzyme Q10) may improve eye health and reduce reactive oxygen species levels [35]. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Speak with your doctor before supplementing. Neuroprotective effect of Pycnogenol® following traumatic brain injury. The staff there can often answer any questions you have and give you more information about specific brands. As a skin powder, however, you can use it safely for up to six weeks.